Ensuring an effective user experience when managing and running scientific HPC software

With CPU clock speeds stagnating over the last few years, ongoing advances in computing power and capabilities are being supported through increasing multi- and many-core parallelism. The resulting cost of locally maintaining large-scale computing infrastructure, combined with the need to perform increasingly large simulations, is leading to the wider use of alternative models of accessing […]

A novel method for quantifying localised correlation of late-gadolinium intensity with conduction velocity

Patient-specific computer models of the human atria have the potential to aid clinical intervention in the treatment of cardiac arrhythmias. However, quantifying and integrating the heterogeneous qualities of the myocardium through imaging is particularly challenging due to the unknown relationship between voxel intensity and tissue conductivities. We establish a method to determine the relationship between […]

A Novel Method for Rotor Tracking Using Bipolar Electrogram Phase

Assessing the location and stability of electrical rotors can help target ablation therapy for atrial fibrillation. Rotor cores can be tracked by identifying singularities in the phase of spatially distributed electrical recordings. This is routinely applied to unipolar electrogram and action potential data, but not to bipolar electrogram data, which contains local activation only. We […]

Elicitation and visualisation of uncertainty in electrograms for activation time maps

When treating atrial arrhythmias using catheter ablation it is standard practice to create local activation maps of a patient’s atrium to guide treatment. Generating these maps involves recording hundreds of electrograms from the inside surface of the chamber and then using automated algorithms to identify deflections in the signal and choose the activation time for […]

A Software Platform for the Comparative Analysis of Electroanatomic and Imaging Data including Conduction Velocity Mapping

Electroanatomic mapping systems collect increasingly large quantities of spatially-distributed electrical data which may be potentially further scrutinized post-operatively to expose mechanistic properties which sustain and perpetuate atrial fibrillation. We describe a modular software platform, developed to post-process and rapidly analyse data exported from electroanatomic mapping systems using a range of existing and novel algorithms. Imaging […]

An Automated Algorithm for Determining Conduction Velocity, Wavefront Direction and Focal Source Location using a Multipolar Catheter

Determining locations of focal arrhythmia sources and quantifying myocardial conduction velocity (CV) are two major challenges in clinical catheter ablation cases. CV, wavefront direction and focal source location can be estimated from multipolar catheter data, but currently available methods are time-consuming, limited to specific electrode configurations, and can be inaccurate. We developed automated algorithms to […]